Pfizer GLP-1 weight loss drug available for pre-order in China

By Andrew Silver

Reuters

SHANGHAI, April 22 (Reuters) - Pfizer’s GLP-1 weight management treatment Xianweiying is available for ‌pre-order in China, a Reuters check on ‌a local e-commerce platform showed, ramping up competition with rivals in ​a market analysts expect to be worth billions of dollars.

A spokesperson for Pfizer did not immediately respond to a request for comment.

A 1.2 ml Xianweiying ‌injector pen with shipping ⁠beginning on April 27 costs 489 yuan ($72), according to one listing on a platform ⁠from JD.com reviewed by Reuters.

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The treatment, belonging to the class of GLP-1 receptor agonist drugs sold locally ​by drugmakers ​such as Novo Nordisk, Eli ​Lilly, and Innovent Biologics, ‌props up Pfizer's footing in the booming weight-loss drug market.

Sales of Novo's Wegovy on Alibaba’s Tmall e-commerce platform and JD.com were 260 million yuan ($38 million) in 2025, against 416 million yuan ($61 million) for Innovent's ‌Xinermei, investment bank Jefferies said ​in a note.

Pfizer licensed the mainland China commercialisation rights for ​Xianweiying, also known ​as ecnoglutide, from Sciwind, based in the ‌eastern city of Hangzhou, in ​February. It ​has also recently acquired the obesity drug developer Metsera, as well as another experimental GLP-1 ​drug from another ‌developer.

Ecnoglutide is also approved in China as ​a treatment for Type 2 diabetes.

(Reporting by Andrew Silver; ​Editing by Kim Coghill)

Pfizer GLP-1 weight loss drug available for pre-order in China

By Andrew Silver SHANGHAI, April 22 (Reuters) - Pfizer’s GLP-1 weight management treatment Xianweiying is available for ‌pre-orde...
Voices: If the PM is to survive his Commons grilling today, here’s what he has to do

“The prime minister is eitherincompetent, gullible or a liar. Or all three.” So tweeted Stephen Flynn MP, the SNP Westminster leader, last week when it emerged that former US ambassador PeterMandelson had failedForeign Office security vetting.

The Independent US

Having repeatedly told Parliament that “full due process was followed”,Keir Starmerinsists he would have blocked the appointment had he known. – and set for a dramatic showdown in the House of Commons over an affair that simply won’t go away.

This afternoon, Starmer’s mission is simple: to update the House on the latest revelations about Mandelson’s appointment, and persuade MPs – not least his own Labour benches – that he is neither incompetent nor a liar. If he can get away with merely being “gullible”, while ​​offering an apology and sufficiently answering difficult questions, he may yet see off those calling for hisresignation.

Preparing for a Commons grilling is not fun. I have worked with my fair share of embattled prime ministers and frontbenchers, and you’d be amazed how many of them would rather be roasted by Jeremy Paxman in his heyday, given an earful by members of the public – or eat akangaroo penis, in the case of Matt Hancock – than be scrutinised by their peers. Getting mentally punched in the head for three hours straight by people you eat, drink and – in some cases – sleep with is no one’s idea of a good time.

Certainly, the prime minister has big, potentially career-altering questions to answer. Are the data points that barred Mandelson from developed vetting status so different from the reports the PM had already received on the “reputational risks” associated with appointing him to the role? Did the PM, perhaps inadvertently, mislead the House when he said in February that Mandelson had passed security checks? If so, why did he not correct the record at the soonest opportunity? And why did he never think to ask about the outcome of the security checks, the ones he insists would have prevented Mandelson from ever being sent to Washington?

Given the speed of developments in AI, who knows ifMinority Report-style technology will one day rule out future prime ministers being able to dodge what they knew, or forgot, or would have done. MPs have now had four days – a luxurious amount of time – to prepare their questions for the prime minister. And Downing Street has had plenty of time to prepare answers.

While the nation waits for the prime minister to appear at the dispatch box, I thought I would offer a sense of what will be going on behind the scenes, right up to the moment that Starmer gets to his feet to speak.

Many were surprised to see theprime minister in Parison Saturday, meeting the French president Emmanuel Macron to discuss the reopening of the Strait of Hormuz. Starmer then travelled from Paris to HMNB Clyde for a defence visit. Why? World leaders and submarines are great optics of him, given that foreign affairs is where the public largely think Starmer is doing a good job.

A strong “getting on with the job” message also contrasts nicely with the grainy photo ofAndy Burnhamloitering on Angela Rayner’s doorstep, which appeared in the Sunday papers. Plus, all that international travel gives him productive time to prep with the PMQs team.

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His diary today will largely have been cleared so that the PM can bone up on his brief before his expected appearance mid-afternoon; ministerial statements and urgent questions are taken from around 3.30pm, depending on how long earlier business takes.

Keir Starmer must ‘persuade MPs – not least his own Labour benches – that he is neither incompetent nor a liar’ (AFP/Getty) (AFP/Getty)

Until that moment, the large ringbinders of files that ministers carry in the Commons – known as the “pack” – will be being constantly updated, as facts are triple-checked and exact wording is worked out. After all, a lot might hang on very precise uses of tenses, modal verbs and so on.

Easy questions will be handed out to friendly MPs hoping for a slot in thenext reshuffle. Members of the cabinet will be bayoneted onto the front bench under strict instructions to nod and frown, and not cry.

His inner circle will be preparing him for his big moment. In my experience, it’s all about the little things, beginning with the basics. Eat some slow-release carbs and, depending on your general tolerance, don’t drink coffee for an hour beforehand, or you’ll be sweating uncomfortably for more than one reason.

As fresh MPs tag-team into the Commons for the second hour, you will gradually run out of steam (hence the slow-release snack). Do not lose your temper. With every question, imagine someone listening who has never even heard of you, and how reasonable you would like them to think you are. Use the soft questions from allies to mentally rest. You know what they’ll say, you know how you’ll answer. Check out for a bit. Think of your favourite Arsenal goals, or what notable eggs there are besides Humpty Dumpty…

Ordeal over, the prime minister will go back to his parliamentary office to hear how the outside world is receiving his apology/defence/memory loss. He will be exhausted, but he will have done it – got through the day, not winning, but still in one piece. His ministers will go on air and say he’s smashed it and that it’s time to move on. All opposition parties will call for his resignation. The sun will set.

Then, as it likes to do, the sun will rise, andOlly Robbins– the now former FCDO permanent secretary who the prime minister sacked last week for overruling security vetting concerns over Mandelson – will have his day in Parliament, at the Foreign Affairs Select Committee, where he will explain his department’s role in the saga.

The prime minister can only hope that Robbins is not one for p***ing into tents.

Cleo Watsonis a former deputy chief of staff to Boris Johnson, and co-host of The Independent’s politics podcast, ‘In The Room’, with ex-deputy cabinet secretary Helen MacNamara. New episodes come out every Friday onApple Podcasts,Spotify, andYouTube

Voices: If the PM is to survive his Commons grilling today, here’s what he has to do

“The prime minister is eitherincompetent, gullible or a liar. Or all three.” So tweeted Stephen Flynn MP, the SNP Westminster leader, l...
LeBron James nets 28 as Lakers grab 2-0 lead on Rockets

LeBron James compiled 28 points, eight rebounds and seven assists to lead the Los Angeles Lakers to a 101-94 victory over the visiting Houston Rockets to take a 2-0 lead in their first-round Western Conference playoff series on Tuesday.

Field Level Media

With leading scorers Luka Doncic (hamstring) and Austin Reaves (oblique) watching from the bench, Marcus Smart added 25 points, including 5 of 7 from 3-point range, and Game 1 hero Luke Kennard contributed 23 points, which included 3 of 6 from deep.

"Just as hard as we played in Game 1, we had to double that in Game 2," James said. "We understood what they wanted to come in (with), the desperation they were going to have, so we had to be even more desperate. And I thought we played a hell of a game."

Kevin Durant, who missed the opening game with a right knee contusion, scored 23 points for Houston, but he had nine turnovers and was held to just three points after halftime.

Houston's Alperen Sengun paired 20 points with 11 rebounds, Jabari Smith Jr. had 18 points and Amen Thompson posted 16 points and nine assists.

After the Rockets held a 16-12 lead midway through the first quarter, Los Angeles hit back, closing the quarter with a 9-0 rush to lead 33-26.

Durant showed no signs of being hampered by his knee, playing all 12 minutes and scoring 11 points.

At the other end, Smart (14 points) and Kennard (10 points) hurt Houston from the perimeter, combining to hit five 3-pointers in the opening quarter.

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The Lakers' lead swelled to 46-31 before Durant led a 17-3 Rockets run to trim that margin to 49-48.

Durant had 20 points on 6-of-7 shooting at the half, but Los Angeles still held sway 54-51.

Houston briefly captured the lead in the third period before the Lakers used a 13-4 burst -- highlighted by a spectacular reverse dunk from 41-year-old James after he blew by Durant -- to pull ahead 67-59.

With Durant held to just one unsuccessful shot attempt in 10 minutes of action for the quarter, the Rockets struggled offensively, outscored 21-17 for the period, as Los Angeles led 75-68 with one quarter to play.

Josh Okogie's 3-pointer with 6:38 remaining in the fourth cut the gap to 85-82, but it was as close as Houston would get down the stretch.

With the Lakers up 97-92, Durant's ninth turnover led to a powerful James dunk with 55.3 seconds left before Kennard sealed it from the stripe.

"The turnovers hurt us, but outside of the third quarter, (we were) decent overall," Rockets coach Ime Udoka said. "But 7-for-29 from three, 8-for-20 on second-chance points, and shooting 40% is not good enough ... (We're) defending well enough, but not scoring. That's the bottom line from these two games."

The best-of-seven series shifts to Houston for Game 3 on Friday.

--Field Level Media

LeBron James nets 28 as Lakers grab 2-0 lead on Rockets

LeBron James compiled 28 points, eight rebounds and seven assists to lead the Los Angeles Lakers to a 101-94 victory over the visiting ...
Shohei Ohtani is making history: What current on-base streak means

Shohei Ohtani is closing in on history.

USA TODAY Sports

TheLos Angeles Dodgers' two-way phenom singled into right field off of Colorado Rockies starter José Quintana in the third inning on Monday night at Coors Field to extend his on-base streak to 52 games. Now, Ohtani enters Tuesday's away series opener against the archrival San Francisco Giants with the opportunity to tie Shawn Green — who reached base safely in 53 consecutive games in 2000 — for second place on the Dodgers' all-time on-base streak list (since 1900).

If Ohtani ties Green with a hit, walk, or hit-by-pitch in any of his plate appearances on Tuesday, he'd be five games away from the franchise record, which belongs to Hall of Famer Duke Snider. He got on base in 58 straight games in the 1954 season.

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Ohtani's streak began back on Aug. 24, 2025. In that time, he's slashed .280/.402/.590 with 56 hits, 16 home runs, 39 walks and three HBPs. He passed “Wee” Willie Keeler (1900-1901) on Sunday to move into third place in the Dodgers' record book after breaking into the top five by surpassing Ron Cey's mark of 47 consecutive games from 1975-76 earlier in the season. On April 10, Ohtani's streak reached 44 games, moving him past Ichiro Suzuki for the longest on-base streak by a Japanese-born player.

“It's a tremendous streak," Dodgers manager Dave Roberts told reporters. "It's hard to get on base, certainly when everyone's trying to target you. This streak is one of the great ones, and hopefully he can keep it going.”

Oct. 17, 2025: Shohei Ohtani celebrates with teammates in the clubhouse after defeating the Milwaukee Brewers in Game 4 of the NLCS at Dodger Stadium. <p style=Oct. 17, 2025: Shohei Ohtani hits a solo home run during Game 4 of the NLCS against the Milwaukee Brewers at Dodger Stadium. Ohtani hit three home runs and pitched six scoreless innings in one of the greatest performances in MLB playoff history. The Dodgers won the game, 5-1, to advance to the World Series.

" style="max-width:100%; height:auto; border-radius:6px; margin:10px 0;" loading="lazy" /> Oct. 4, 2025: Shohei Ohtani made his first postseason pitching appearance in NLDS Game 1 against the Philadelphia Phillies at Citizens Bank Park. The Los Angeles Dodgers prevailed, 5-3, and Ohtani got the win. Sept. 9, 2025: Shohei Ohtani steals second base under the tag of Colorado Rockies second baseman Tyler Freeman during the third inning at Dodger Stadium. Aug. 27, 2025: Shohei Ohtani is interviewed by Spectrum SportsNet reporter David Vassegh (right) alongside translator Will Ireton after a game against the Cincinnati Reds at Dodger Stadium. Aug. 20, 2025: Shohei Ohtani delivers a pitch during the first inning against the Colorado Rockies at Coors Field. July 15, 2025: Shohei Ohtani does an interview on the red carpet before the 2025 MLB All-Star Game at Truist Park in Atlanta. June 16, 2025: Shohei Ohtani makes his pitching debut for the Los Angeles Dodgers against the San Diego Padres at Dodger Stadium. April 2, 2025: Shohei Ohtani is greeted at home after hitting a walk-off home run against the Atlanta Braves during the ninth inning at Dodger Stadium. The Los Angeles Dodgers won the game, 6-5, on what was Shohei Ohtani bobblehead night. March 19, 2025: Shohei Ohtani is introduced and enters the field before the Los Angeles Dodgers' game against the Chicago Cubs during the Tokyo Series at Tokyo Dome. The Dodgers won the game, 6-3. March 18, 2025: The scoreboard at the Tokyo Dome shows a photo of the Los Angeles Dodgers' Shohei Ohtani before the season opener against the Chicago Cubs during the Tokyo Series. The Dodgers won the game, 4-1. Nov. 1, 2024: Shohei Ohtani holds his dog, Decoy, as he walks with off the field his wife Mamiko Tanaka following the Los Angeles Dodgers' World Series championship celebration at Dodger Stadium. Oct. 31, 2024: Shohei Ohtani celebrates with the Commissioner’s Trophy after the Los Angeles Dodgers defeated the New York Yankees in Game 4 to win the 2024 World Series at Yankee Stadium. Oct. 30, 2024: Shohei Ohtani (17) and the Los Angeles Dodgers celebrate after defeating the New York Yankees in Game 4 to win the 2024 World Series at Yankee Stadium. Sept. 19, 2024: Shohei Ohtani reacts to a standing ovation from the fans after hitting his 50th home run of the season. He hit it against the Miami Marlins during the seventh inning at loanDepot Park. Aug. 28, 2024: Shohei Ohtani with his dog Decoy after he delivered he first pitch before a game against the Baltimore Orioles at Dodger Stadium. Aug. 24: Shohei Ohtani is doused after he joined the 40-40 club with a walk-off grand slam. July 25, 2024: Shohei Ohtani runs the bases after hitting a solo home run against the San Francisco Giants during the eighth inning at Dodger Stadium. July 16, 2024: Shohei Ohtani celebrates after hitting a three-run home run during the third inning of the 2024 MLB All-Star Game at Globe Life Field. July 16, 2024: Shohei Ohtani walks the red carpet with wife Mamiko Tanaka before the 2024 MLB All-Star Game at Globe Life Field. April 29, 2024: Shohei Ohtani breaks for third base against the Diamondbacks. April 26, 2024: Shohei Ohtani rounds the bases after hitting a home run against the Blue Jays. April 24, 2024: Shohei Ohtani gestures to his dugout at second base after hitting an RBI double against the Nationals. April 23, 2024: Shohei Ohtani in the outfield during a throwing session prior to the Dodgers' game. April 21, 2024: Shohei Ohtani hits a solo homer against the Mets during the third inning at Dodger Stadium. April 12, 2024: Shohei Ohtani is showered with sunflower seeds after hitting a solo home run in the first inning against the Padres. April 9, 2024: Shohei Ohtani hits a fly ball against the Minnesota Twins at Target Field. April 7, 2024: Shohei Ohtani gestures after hitting a one-run double against the Cubs at Wrigley Field. April 5, 2024: Shohei Ohtani hits a two-run home run against the Cubs at Wrigley Field. April 2, 2024: Shohei Ohtani waits on deck in the first inning against the Giants at Dodger Stadium. March 28, 2024: Shohei Ohtani makes his Opening Day debut against the St. Louis Cardinals at Dodger Stadium. <p style=March 20, 2024: Shohei Ohtani gets his first hit as a Dodger in the third inning during the 2024 Seoul Series game against the Padres.

" style="max-width:100%; height:auto; border-radius:6px; margin:10px 0;" loading="lazy" /> March 20, 2024: Mamiko Tanaka, wife of Shohei Ohtani, watches Ohtani's debut as a Dodger in the season opener in Seoul, South Korea. March 13, 2024: Shohei Ohtani signs autographs before the spring training game against the Seattle Mariners at Camelback Ranch. March 5, 2024: Shohei Ohtani talks with former Los Angeles Angels teammate Mike Trout before a spring game. March 3, 2024: Shohei Ohtani looks on from the dugout during a spring training game against the Colorado Rockies at Camelback Ranch. Feb 21, 2024: Shohei Ohtani (left) and pitcher Yoshinobu Yamamoto poses during picture day at Camelback Ranch. Feb 21, 2024: Shohei Ohtani poses for a portrait during picture day at Camelback Ranch. Feb. 14, 2024: Shohei Ohtani takes batting practice during a Spring Training workout at Camelback Ranch. Dec. 21, 2023: Shohei Ohtani and interpreter Ippei Mizuhara (right) pose with Los Angeles Rams mascot Rampage at SoFi Stadium. Dec. 14, 2023: Shohei Ohtani and Dodgers manager Dave Roberts pose for pictures during the press conference. Dec. 14, 2023: Shohei Ohtani is introduced by the Los Angeles Dodgers for the first time at a press conference at Dodger Stadium.

Shohei Ohtani: Dodgers' $700 million man in photos

If Ohtani can pass Snider's benchmark, he'd still be a ways away from Ted Williams' MLB record of 84 straight games reaching base in 1949.

This article originally appeared on USA TODAY:Shohei Ohtani on-base streak: What to know

Shohei Ohtani is making history: What current on-base streak means

Shohei Ohtani is closing in on history. TheLos Angeles Dodgers' two-way phenom singled into right field off of Colorado Rocki...

 

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